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Regression testing should be prioritized whenever changes are introduced into an existing application, including new features, bug fixes, configuration updates, or dependency upgrades. Each of these changes carries the risk of impacting previously stable functionality, making regression testing essential for risk mitigation.

By running regression testing at key stages of development, teams can identify defects early, reduce last-minute surprises, and avoid costly rollbacks after release. This practice is particularly important in agile and continuous delivery environments, where rapid iterations leave little time for extensive manual verification.

Consistent regression testing builds confidence in release readiness. It helps teams maintain application stability, protect core user flows, and ensure that frequent updates do not compromise the overall reliability of the software.